The production of interleukin (IL)-1, IL-6, IL-12, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α promotes Th1 differentiation; IL-17A, IL-17F, IL-21, IL-22, and IFN-γ promote Th17 differentiation; IL-4, IL-5, IL-13, IL-9, and IL-6 promote Th2 differentiation involved in allergic reactions [4,53,54]. This evidence concerns the gene TNF and allergic disease.