TNF and Disseminated intravascular coagulation: From the pathophysiological point of view, an increase in proinflammatory cytokines such as interleukins 6 and 2 (IL-6 and IL-2), but also tumor necrosis factor-alpha (TNF-α), causes damage to the endothelium, which further generates coagulation cascade, which is the key cause of disseminated intravascular coagulation (DIC), thromboembolic events, or bleeding [10].