However, the identification of the ALT+ cells is much more tedious and has to rely on the positivity of multiple assays, including telomere fluorescent in situ hybridization (Telo-FISH), ALT-associated acute promyelocytic leukemia bodies (APBs), telomere dysfunction induced foci (TIFs), telomere sister chromatin exchange (tSCE), C-circle, and others [7,9]. This evidence concerns the gene GPT and acute promyelocytic leukemia.