Familial hypercholesterolemia (FH) is a dominant hereditary metabolic disorder usually related to pathogenic variants in the LDLR (low-density lipoprotein receptor), APOB (apolipoprotein B) or PCSK9 (proprotein convertase subtilisin/kexin type 9) genes. The gene discussed is PCSK9; the disease is familial hyperaldosteronism.