DAPK1 and early-onset autosomal dominant Alzheimer disease: DAPK-1 deregulation also contributes to neurological disorders including ischemic stroke [21] and Alzheimer’s disease [22] by directly phosphorylating Tau on Ser262, resulting in cortical neuron spine damage [23] and also through its involvement in the neurotoxicity of amyloid-β (Aβ) [24,25].