CircRNA hsa_circRNA_104348 is significantly upregulated in HCC (hepatocellular carcinoma) tissues and cells, and the circRNA hsa_circRNA_104348 may act as a competitive endogenous RNA that affects HCC cell proliferation, migration, invasion and apoptosis by targeting miR-187-3p and RTKN2 (Rhotekin2) and activating the Wnt/β-catenin pathway to promote HCC progression [19]. Here, RTKN2 is linked to hepatocellular carcinoma.