In diabetic cardiomyopathy (DCM), cyclic RNA cerebellar degeneration-associated protein 1 antisense (Circ-CDR1as) promotes cardiomyocyte apoptosis by activating the Hippo signaling pathway through significant inhibition of mammalian sterile 20-like kinase 1 (MST1) ubiquitination levels [23]. Here, MST1 is linked to familial dilated cardiomyopathy.