Such an effect could be explained by the association of the studied SNP with inflammatory markers, such as C-reactive protein [45], known for its influence on cardiovascular risk and atherosclerosis progression [46], and also by the link of the variant with metabolic syndrome [47] and glucose levels [48], taking into account the known role of hyperglycemia in the dysfunction of the endothelium [49,50]. This evidence concerns the gene CRP and metabolic syndrome.