The presence of the link with CIMT change and the absence of any association with lipid level change suggest that the pharmacogenetic effect on CIMT change might be mediated through non-lipid-related mechanisms, taking into account that SNP rs4846914 is known to be associated with endothelial function, serum levels of insulin and glucose [39], as well as hypertension [40]. This evidence concerns the gene INS and hypertensive disorder.