The paper by Huan R.S.P. et al. [29] is very interesting, in which the authors analysed 1268 melanoma samples for which an IHC investigation for PD-L1 was requested and which were divided into high-pigmented melanoma (HPMel) and low-pigmented melanoma (LPMel), constituting 13.0% and 87.0% of the sample, respectively. The gene discussed is CD274; the disease is melanoma.