Of great interest was the relationship found between CD8+ TIL expression and PD-L1 in a cohort of patients studied by Skuciova V. et al. [24], in which immunohistochemistry for PD-L1 and CD8 was performed on 56 formalin-fixed paraffin-embedded samples from patients with cutaneous and metastatic malignant melanomas using clone 28-8 and then, tumour proportion scores (TPS) were assessed. This evidence concerns the gene CD8A and melanoma.