SHMT2 and thalassemia: DEGs that were upregulated after vitrification and associated with decreased oocyte developmental competence included the following: Insulin-like growth factor binding protein 3 (IGFBP3), Ndr4 (NDRG4), α thalassemia/mental retardation syndrome X-linked/chromatin remodeler (ATRX), Serine hydroxymethyltransferase 2 (SHMT2), Mediator complex subunit 1 (MED1), Solute carrier family 39 member 14 (SLC39A14), RNA binding motif single stranded interactingprotein 1 (RBMS1), Transforming growth factor β receptor III (TGFBR3), and Mitogen-activated protein 3 kinase 12 (MAP3K12) [27].