It has also been shown that myocardial injury may induce c-kit+ cells to exhibit cardiomyocyte-specific gene expression and Sfrp2 enhances this effect [97], and, lastly, the same group has claimed that Sfrp2 induces cardiomyocyte differentiation in c-kit+ cells in vivo in health and MI, as revealed by genetic lineage tracing and functional assessment of the developed CMs [98]. Here, SFRP2 is linked to myocardial infarction.