In addition, LTB4, the metabolite of ALOX5, can influence ERK1/2 to promote CRC cell proliferation or enhance the secretion of TNF-α and heparin combined with epidermal growth factor-like growth factors through the upregulation of the expression of matrix metalloproteinases, thereby promoting the occurrence and development of tumors [42]. The gene discussed is ALOX5; the disease is colorectal carcinoma.