The fact that ALOX5 is not expressed in most normal epithelial cells has been reported extensively, whereas ALOX5 and its pathway-related proteins are significantly upregulated in a plethora of tumor cells, including CRC (colorectal cancer) and esophageal cancer, and their expression is closely related to tumor metastasis and poor prognosis of patients [41]. The gene discussed is ALOX5; the disease is neoplasm.