Further supporting this statement, in a recent study, it was noted that DEFA4 (for defensin α 4), LYZ (for lysozyme) and HTN3 (for histatin 3) expression levels showed high sensitivity and specificity regarding their detection and were significantly different between healthy sites and those affected by periodontitis, proving they could be a useful diagnostic indicator in the future. The gene discussed is HTN3; the disease is periodontitis.