MGMT and cancer: Based on recent studies of our own and others, we have enumerated six molecules, which upon mutation are regarded as the primary cause of cancer development and are as follows: isocitrate dehydrogenase, telomerase reverse transcriptase, BRAF, O6-methylguanine-DNA methyltransferase, histone3-lysine27/histone3-guanine34, and NTRK/ROS1.