Saleheen et al. [17] reported severe XLRS phenotypes in four sisters who were homozygous for a novel c.579dupC variant in exon 6 of the RS1 gene; all presented early in life, with one presenting at 1 year old with bilateral retinal detachment and retinoschisis with macular involvement; a 3-year-old had bilateral complete retinal detachments. This evidence concerns the gene RS1 and retinoschisis.