While the roles of RAAS genes, such as angiotensin-converting enzyme (ACE), angiotensinogen (AGT), angiotensin II receptor type 1 (AGTR1) and aldosterone synthase (CYP11B2) in hypertension were previously extensively studied in various ethnicities, few studies conducted regarding the Pashtun population exist [18,19,20,21,22,23,24]. The gene discussed is ACE; the disease is hypertensive disorder.