CYP11B2 and hypertensive disorder: Aldosterone gene CYP11B2 polymorphisms are associated with many diseases, such as Type 2 Diabetes Mellitus (T2DM) [50,51,52], myocardial infarction (MI) [53], left ventricular mass [54,55], hyperaldosteronism [56], arterial stiffness [57] and hypertension [58,59,60,61].