Furthermore, the genes enriched in GO terms and genes corresponding to the highest iHS scores were reported to be associated with various properties, including visual impairment (SLITRK6, TNFRSF21, TENM3 and FAM161A,) [44,45,46,47], hearing loss (SLITRK6, SLC52A3, SLC26A4, MPZL2, LOXHD1 and GRM7) [48,49,50,51,52] and neural development (TSHR, C2CD3 and NRG1) [30], which possibly reflects the most critical changes in the brain and neural development traits that occurred during the early stage of domestication in YZD goats. This evidence concerns the gene SLC52A3 and hearing loss disorder.