Furthermore, the genes enriched in GO terms and genes corresponding to the highest iHS scores were reported to be associated with various properties, including visual impairment (SLITRK6, TNFRSF21, TENM3 and FAM161A,) [44,45,46,47], hearing loss (SLITRK6, SLC52A3, SLC26A4, MPZL2, LOXHD1 and GRM7) [48,49,50,51,52] and neural development (TSHR, C2CD3 and NRG1) [30], which possibly reflects the most critical changes in the brain and neural development traits that occurred during the early stage of domestication in YZD goats. The gene discussed is TNFRSF21; the disease is hearing loss disorder.