ZMYND8 and neoplasm: We observed increased 5hmC levels in H3K4me3 regions in genes relating to cell proliferation, such as CDK6 [37] and ZMYND8 [38], and reduced 5hmC levels in H3K4me3 regions in genes that may be related to tumor suppression, such as ARHGAP26 [39] and GLI3 [40].