PGR and breast carcinoma: Figure 4B illustrates that GMFG’s mRNA expression has potential activation effects on apoptosis and EMT pathways in breast cancer but potential inhibitory effects on the cell cycle, hormone ER, and PR pathways. We didn’t find any relationship between GMFG mRNA expression and the PI3K/AKT, RTK, or TSC/mTOR pathways in breast cancer (Figure 4B).