HNRNPH2 and Global developmental delay: We initially described the clinical phenotype and have expanded on the natural history of HNRNPH2-RNDD (OMIM 300986, Intellectual developmental disorder, X-linked syndromic, Bain-type), presenting with developmental delay/intellectual disability, severe language impairment, motor problems, growth, and musculoskeletal disturbances [16,17,19].