On the other hand, the inhibition of STAT5b in HeLa (HPV18) and CasKi (HPV16) cervical cancer cells induces a reduction in proliferation, in the colony formation capacity, in the expression of cyclin D1, and in the anti-apoptotic protein Bcl-xL, which correlates with an increase in the expression of the cell cycle regulatory protein p21, the presence of cleaved PARP, and an increase in apoptosis. The gene discussed is STAT5B; the disease is cervical carcinoma.