Recognizing complex (three-way translocations) and cryptic (translocations/insertions/inversions) EWSR1::FLI1 and EWSR1::ERG gene fusions along with other chromosome abnormalities (such as 1q jumping translocations, tetrasomy, aneuploidies, and structural chromosomal abnormalities) using a combination of various diagnostic methods is important for accurate diagnosis, prognosis, and treatment outcomes of pediatric Ewing sarcomas. The gene discussed is EWSR1; the disease is Ewing sarcoma.