The EWSR1::FLI1 gene fusion occurs in approximately 85% of ESs, followed by EWSR1::ERG gene fusion occurring in approximately 5% of ESs, and other EWSR1 fusions/rearrangements at a much lower frequency, all of which are cancer-specific chimeric transcription factors that enormously restore the transcriptome leading to tumorigenesis of ES [4,5,6,7]. The gene discussed is EWSR1; the disease is cancer.