Based on these facts, our objective was to study the potential association of the SNPs in DNMT1 (rs2228611), DNMT3A (rs7590760), and DNMT3B (rs6087990), as well as the methylation profiles of these genes, with chemo-induced OM in children and adolescents undergoing treatment for hematologic malignancies with MTX®. Here, DNMT1 is linked to hematologic disorder.