In the case of T1D, most reports employ quantification of soluble NET remnants such as MPO, PR3, NE, and citrullinated histones (CitH3), as end-point surrogate markers of NETosis and do not objectively quantify the sequential dynamics and morphological changes of NETing neutrophils overtime [18,19,20,21,22]. The gene discussed is PRTN3; the disease is type 1 diabetes mellitus.