INS and obesity due to melanocortin 4 receptor deficiency: Additionally, these young adults with obesity elicited greater microtubule-associated protein 1A/1B-light chain 2 (LC3-II) to microtubule-associated protein 1A/1B-light chain 1 (LC3-I) ratio and LC3-II/LC3-I AUCi (potentially elevating autophagic activity) when compared to normal-weight subjects in response to maximal aerobic exercise [29], along with a positive relationship BMI, waist/hip ratio, and fasting insulin levels [29].