ESR1 and breast carcinoma: On the other hand, 17-β-estradiol induces estrogen receptor 1 (ESR1)-positive breast cancer proliferation and invasive capacity through altered cellular lipid metabolism, resulting in cellular uptake of the polyunsaturated fatty acids AA and eicosapentaenoic acid (EPA) and increased ACSL4 protein levels through non-transcriptional means [173].