For instance, adipocyte-specific knockout of Acsl4 in mice (Ad-KO mice) protects against high-fat diet-induced obesity, inhibits adipocyte death, and effectively prevents increased fat and liver fat accumulation by inducing gonadal white adipose tissue oxygen consumption and whole-body energy expenditure [112]. The gene discussed is ACSL4; the disease is obesity due to melanocortin 4 receptor deficiency.