On the other hand, M2-polarized macrophages, driven by M-CSF, TGF-B, IL-4, IL-10 and IL-13, are believed to promote wound healing, angiogenesis and tumor growth by producing tumor growth factor (TGF)-β, IL-10, CCL17, CCL18, CCL22, CD206, CD204 and CD163 [62]. This evidence concerns the gene TGFB1 and neoplasm.