TGFB1 and cancer: Of the myriad of soluble factors identified from the secretome of cancer cells, ligands belonging to the TGF-β superfamily [45,46], platelet-derived growth factors (PDGFs) [47], inflammatory cytokines, and chemokines such as interleukins (IL) [48], and more recently, exosomes and macrovesicles [49] have been implicated in this transformative process.