Irregular expression of EMT markers, including E-cadherin, platelet-derived growth factor D (PDGF-D), Notch-1, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), vimentin, and zinc finger E-box binding homeobox 1 (ZEB-1) have been observed with Notch-1 expression considered the signature for the acquirement of EMT in PCa bone metastasis [32,33,34]. This evidence concerns the gene ZEB1 and posterior cortical atrophy.