Three comorbidities were negatively correlated with the infection in both groups, including obesity (53% vs. 46% for the HDL group and 53% vs. 44% for the apoA1 group; both p < 0.001); chronic lung disease (29% vs. 20% for the HDL group, and 35% vs. 27% for the apoA1 group; both p < 0.001); HIV (1.2% vs. 0.7% for the HDL group, and 5.9% vs. <3.12% for the apoA1 group; both p < 0.001), and depression (29% vs. 21% for the HDL group, and 40% vs. 33% for the apoA1 group; both p < 0.001). Here, APOA1 is linked to obesity due to melanocortin 4 receptor deficiency.