Likewise, Sengupta et al. [60], in a previous analysis of the expression of MMP and TIMP in the central nervous system, after infection with the murine hepatitis virus (a member of the β-coronavirus genus, as well as SARS-CoV-2 and MERS-CoV), indicated that the increase in circulating levels of MMP-3 mRNA, MMP-12, and TIMP-1 are correlated with high viral replication [60]. The gene discussed is TIMP1; the disease is infection.