The importance of this parameter is evidenced by the data that patients with CHC show reduced CD4+/CD8+ ratios compared to the healthy control group, and patients with F3-F4 liver fibrosis and cirrhosis demonstrate much lower CD4+/CD8+ ratios than patients with F0-F2 fibrosis and fatty liver do [53,54,55]. This evidence concerns the gene CD8A and Hepatic fibrosis.