SERPINB3 and hepatocellular carcinoma: Based on our previous studies on the increase in cellular proliferation promoted by SerpinB3 in hepatoma cells [15], we have evaluated whether this serpin is able to increase proliferation in monocytes, since monocytic cells are the main type of inflammatory cells in the tumor microenvironment and are profoundly involved in the pathogenesis and development of primary liver tumors, establishing a pro-inflammatory and pro-tumorigenic environment by the suppression of antitumor immune responses [23].