BRAF and melanoma: Interestingly, the presence of the BRAF mutation was found to be involved in regulating oxidative stress since it can be associated with enhanced glycolytic metabolism and lowering mitochondrial oxidative phosphorylation (OXPHOS), one of the main sources of ROS production; however, BRAFi/MEKi-resistant melanoma cells show an enhancement of mitochondrial biogenesis, activity, and content, leading to a further increase in mitochondrial ROS production [51,52].