SIRT3 and endothelial dysfunction: Given the results concerning SIRT3 negative modulation and considering the critical role of this sirtuin in diabetes-associated oxidative stress and endothelial dysfunction [45], we explored whether SIRT3 silencing (p < 0.001 vs. NT) (Figure 6A) could affect the beneficial effects of 3-kDa WH on T2DM-induced stress.