To assess the role of OLA dietary treatment in epigenetic modifications, we studied the expression of several miRNAs involved in SLE pathogenesis (miRNA-146a, miRNA-23b, miRNA-126, and miRNA-24-3p) and also the expression of DNMT-1 in renal tissue from pristane-induced mice. The gene discussed is DNMT1; the disease is systemic lupus erythematosus.