NFKB1 and lobular neoplasia: In addition, different diets enriched with EVOO bioactive compounds, including hydroxytyrosol, oleuropein, and oleocanthal, could regulate JAK-STAT, mitogen-activated protein kinases (MAPKs), and NF-κB signaling pathways and the production of pro-inflammatory biomarkers, leading to attenuated LN [9,13,14].