In order to further elucidate the possible molecular mechanisms involved in the immunomodulatory effects of an OLA-enriched diet, we evaluated the protein expression of several signaling pathways implicated in SLE pathogenesis: MAPKs, the Nrf-2/HO-1 axis, JAK3/STAT3 phosphorylation, and the NF-κB signaling pathways. Here, HMOX1 is linked to systemic lupus erythematosus.