For example, in mouse models of atherosclerosis, systemic lupus erythematosus, and gastrointestinal inflammation, Ogg1 deficiency exacerbates the inflammatory response and accelerates the disease process [28,71,72], whereas, in allergic airway inflammation and asthma, Ogg1 acts as a pro-inflammatory agent [34,73]. Here, OGG1 is linked to asthma.