OGG1 and asthma: In addition, in mouse asthma models induced by ovalbumin (OVA), TH5487, a small molecule inhibitor of OGG1, was found to significantly inhibit plasma levels of Immunoglobulin E(IgE) and the recruitment of eosinophils and other immune cells to the lungs, while also downregulating the expression of tumor necrosis factor receptor superfamily member 4, arginase 1, Chemokine (C-C motif) ligand 12 and Chemokine (C-C motif) ligand 11, and decreasing levels of activated nuclear factor kappa-B(NF-κB) [25,26,27].