Ogg1−/− mice were found to resist endogenous toxicity-induced organ dysfunction, neutrophil infiltration, and oxidative stress, but at the same time, Ogg1−/− mice fed a high-fat diet exhibited higher fasting plasma insulin levels and increased susceptibility to obesity and diabetes [11,12]. The gene discussed is OGG1; the disease is obesity due to melanocortin 4 receptor deficiency.