Among several signaling involved pathways (NF-kB, p38 MAPK, JNK/SAPK), the activation of the nuclear factor-kappa B (NF-kB) transcription factor and the NLRP3 inflammasome (“the nucleotide-binding and oligomerization domain, leucine-rich repeat, and pyrin domain-containing 3”) play an essential role in metabolic diseases pathogenesis [57]. The gene discussed is NFKB1; the disease is metabolic disease.