FeTPPS significantly inhibited peroxynitrite generation, tyrosine nitration, the dissipation of MMP, and the activation of caspases 3 and 9 in response to interferon-gamma, and the reduction in cell viability was markedly rescued by FeTPPS in interferon-gamma-treated cancer cell lines of hepatoma and fibrosarcoma [28]. This evidence concerns the gene CASP3 and hepatocellular carcinoma.