In a model of sepsis, FeTPPS prevented the accumulation of peroxynitrite and heart nitrotyrosine staining and improved endotoxin-induced myocardial contractile dysfunction, which was associated with the reduced degradation of nuclear factor kappa B inhibitory protein I-kappa-B, plasma TNF-alpha levels, and microvascular endothelial cell-leukocyte activation [30]. This evidence concerns the gene TNF and Sepsis.