Histopathological evaluation of kidney tissues revealed a large range of diabetes-associated lesions in Cndp1-KO and WT mice on ND and HFD (Table 2), including fibrosis of Bowman’s capsule, glomerular mesangial expansion and sclerosis, tubular protein cylinders, tubular dilation, fibrosis and atrophy and interstitial inflammation and fibrosis. Here, CNDP1 is linked to diabetes mellitus.