Last, TERT promoter somatic mutations along with 8p loss were shown to be characteristic genomic changes of HCC secondary to MAFLD, frequently accompanied by TP53 as well as SWI/SNF complex constituents (ARID1A and ARID2) mutations, clarifying the landscape of genomic instability in these patients [106]. This evidence concerns the gene TERT and hepatocellular carcinoma.