CD4 and Alzheimer disease: We found that EEVP lowered the number of various inflammatory cells including T cells (CD3+, CD4+, CD8+, CD4+/CD69+), IgE-producing CD23+B220+ B cells, and eosinophils (Gr-1+CD11b+) in dorsal skin, ALNs, and PBMCs of an AD mouse model, similar to that in a previous report [25].