TNF and metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials (RCT = 24) conducted by Tabrizi et al. showed that RSVL supplementation significantly decreases hs-CRP (standardized mean difference (SMD), −0.55; 95% CI, −0.84, −0.26; p < 0.001; I2: 84.0) and TNF-α levels (SMD, −0.68; 95% CI, −1.08, −0.28; p = 0.001; I2: 81.3) among patients with metabolic syndrome, with no changes in Il-6 and SOD concentrations [104].