Interestingly, the higher upregulation of the Beclin-1 and LC3-II was recorded in the T2DM-Lip-BBR + Vild group, and there was no significant difference in the level of immunoexpression of both biomarkers between the T2DM-Lip-BBR and T2DM-Vild groups. This evidence concerns the gene BECN1 and type 2 diabetes mellitus.