FSP1 (AIFM2) was initially identified as a p53 target gene that is induced during p53-dependent apoptosis in human colon cancer cells, and it was referred to as an AIF-homologous mitochondrion-associated inducer of death (AMID) or p53-responsive gene 3 (PRG3) [33]. This evidence concerns the gene AIFM2 and malignant colon neoplasm.