HO-1 was indicated to be highly induced in multiple cancers, such as breast cancer [30], liver cancer [31], gastric cancer [32], colorectal cancer [33], esophageal squamous cell carcinoma [34], prostate cancer [35], pancreatic cancer [36], and neuroblastoma [37], and was closely related to poor patient prognosis. The gene discussed is HMOX1; the disease is neuroblastoma.