Survival analysis in the PrognoScan database (www.prognoscan.org/, accessed on 10 March 2023) provided strong evidence that high HO-1 mRNA expression predicts significantly worse prognosis in lung cancer, breast cancer, blood cancer, brain cancer, colorectal cancer, and ovarian cancer (Figure 2). Here, HMOX1 is linked to hematopoietic and lymphoid system neoplasm.