Wang et al. found that GRIM-19 deficiency resulted in aberrant HO-1 activation in a ROS-Nrf2 axis-dependent manner in gastric cancer cells, along with significantly increased HO-1 expression in metastatic lung and liver tissues, while HO-1 inhibition limited GC cell migration and invasion and directly abrogated GC metastasis in vivo [138]. This evidence concerns the gene HMOX1 and gastric cancer.