AKT1 and hepatocellular carcinoma: Yamada et al. used the HuH7 cell line, a hepatocarcinoma cell line, and found that quercetin was able to suppress the migration of HCC cells through the attenuation of AKT signaling, and that suppression of the hepatocyte growth factor (HGF) and transforming growth factor-α (TGF-α) are involved in the molecular mechanism [162].