CYP1B1 and pulmonary fibrosis: Genetic polymorphisms in SNPs related to ROS metabolism, such as cytochrome P450 Family 1 subfamily A Member 1 (CYP1A1) and cytochrome P450 Family 1 subfamily B Member 1 (CYP1B1), as well as antioxidant enzymes, such as GST and SOD, increase susceptibility to CS-induced pulmonary fibrosis [239,240].