The mechanism by which H2S potentiates the analgesic effects of CB2R agonists might be related to the preservation of the high levels of CB2R, together with the inhibition of inflammation, oxidative stress and the BDNF overexpression produced by DADS and GYY4137 in the PFC and/or PAG of animals with neuropathic pain. Here, BDNF is linked to neuropathic pain.