Indeed, the upregulation of proBDNF in the hippocampus of animals with anxiety- and depressive-like behaviors associated with peripheral inflammation [67], and the downregulation of mBDNF in the anterior cingulate cortex of mice with anxiodepressive-like behaviors accompanying neuropathic pain [68], support the different roles played by both forms of BDNF in regulating these affective disorders. This evidence concerns the gene BDNF and Anxiety.