Similarly, the impact of CORM-A1 on the development of diabetes has been evaluated in murine models, with CORM-A1 decreasing the incidence of diabetes in NOD mice, which was associated with an attenuated activity of M1 macrophages and the induction of CD4+ T cell differentiation toward a Th2 phenotype instead of Th1 or Th17 T helper cells [64]. This evidence concerns the gene CD4 and diabetes mellitus.