However, the T cell-activating capacity of HO-1-expressing DCs may differ in the context of viral infections, such as with HSV, as this virus encodes molecular determinants that are recognized by pathogen recognition receptors (PRRs) expressed in DCs, which will likely elicit signaling cascades within HO-1-expressing infected cells that can modulate the overall phenotype of these DCs [53,54,55]. The gene discussed is HMOX1; the disease is viral infectious disease.