TGFB1 and Myocardial fibrosis: However, in an animal model of streptozotocin-induced diabetic cardiomyopathy, the administration of pomegranate peel extract (150 mg/kg BW) exhibited a significant reduction in myocardial fibrosis, reflected by lowering the cardiac myofibrils reactivity against TGF-β and collagen fiber deposition [75].