PHLPP2 and Hepatic fibrosis: Studies have shown that hyperoside has an anti-inflammatory and antioxidant profile that may help to protect the liver from damage and slow the progression of liver fibrosis, by suppressing canonical NF-κB signaling [16], via upregulation of Nrf2 [17], or via the PHLPP2-AKT-GSK-3β signaling pathway [18].